Dr. Marie Badalemente is a current professor of Orthopaedics at Stony Brook University and a member of the National Academy of Inventors. Her research focuses on studying and developing alternative non-invasive treatment options. Her research on collagenase clostridium histolyticum (CCH) was the first FDA-approved non-surgical injection treatment for Dupuytren’s contracture, Xiaflex.

Collagenase for treating cellulite

The invention discovered the effectiveness of collagenase in treating cellulite in humans. By injecting sufficient amounts of collagenase, the injections are able to lyse the collagen network of cellulite and eliminate the appearance of cellulite on the skin. These collagenase injections are also presented to be used as treatment for Dupuytren’s disease, adhesive capsulitis and Peyronie’s disease.

Method for treating lateral epicondylitis using collagenase

The invention discovered a method to treat carpel tunnel, plantar fasciitis and lateral epicondylitis by injecting collagenase. These conditions cause inflammation and fibrosis of collagen tissue and results in pain in the affected areas. Collagenase injections are effective in purifying collagenase to collagenase adhesions of targeted areas and present as a non-surgical treatment option for carpel tunnel syndrome, plantar fasciitis and other applicable conditions.